The closest event of poisoning or drugging a people to kill them was the genocide of the native Indians when the early white migrants put on the pretence of kindness, offering blankets and clothing tainted with European diseases to them. Under such deceit of kindness and generosity, the victims would often put down their guards and accept the gift in good faith only to their demise. For a party to intentionally do such a devious act, by force, to a whole people, would be difficult and unthinkable.
The Japanese had a biochemical lab in Manchuria during WW2 named Unit 731 where they forcefully injected poisons and chemicals on their victims made up of mainly Chinese, Koreans and Russians. They could do it on a small number of people at a time. They also did that to some Chinese villages to kill them en mass. But to do that on a national scale to kill the whole Chinese population or in a big scale would be difficult unlike the case of native Americans.
The next closest form of such a hideous act was the selling of opium to the Chinese population by the British in the 19th Century. Here it was not by force initially but by deceit that it was a wonderful drug and the Chinese fell for it, thus is a way willingly consuming the drug with no compulsion, a willing victim.
The Americans also spread some of these toxic staff in North Korea and Vietnam, Agent Orange and Purple Rain, and achieved some results on a limited scale on the North Koreans and Vietnamese.
There are two elements to the success of mass drugging or poisoning, deceit and a willingness by the victims to accept the drug or poison. It is unlikely that such a wicked plan could be introduced in modern civilisation when the people are much well informed of the danger of drugs and poison, though still many would still consume drugs by self deception or delusion that the drugs are safe and would not kill them.
Today the world is experimenting with a new drug, called vaccine, for Covid19. This is a new experimental drug, not sure how thorough is the research on its side effects or harm that it might inflict on the users. The two biggest white nations, UK and US, are promoting the use of these vaccines using a new technology involving splicing and manipulating DNA/RNA. Some trials have been done on small samples of volunteers and only a few months have passed and the vaccines are approved for emergency use, for desperate countries like the US and UK. But many other countries that are not so desperate are also rushing in, buying these vaccines in the millions for their people instead of the traditional proven vaccines that used deactivated Covid19 virus to induce a response to build up anti bodies in the recipients.
All is good if the western vaccines eventually proved themselves to be worthy and effective without major side effects. What if, what if the side effects would appear after a longer span of time, maybe a year, or several years down the line, when the human body reacts with the RNA and new DNAs evolved leading to mutants being created? What the crazy Bolsonaro of Brazil said about man turning into crocodiles or woman growing beard or whatever that were not supposed to happen may be wild and hilarious and not likely to happen. What if?
Today, many American leaders are cutting queues to be first to be vaccinated with the new vaccines to set an example, to build confidence that the vaccines are safe, some really believed so and jumping queues to be the first to be protected. What if a few years down the line things untoward start to happen, when the recipients of such vaccines developed into other forms, or their DNA got hacked by the RNA introduced into their bodies from the vaccines? If these new vaccines turned foul and bad in the future, it would be a classic case of human civilisation willingly accepting the vaccines to destroy themselves en mass, not by force, not by deceit, but by misinformation or lack of in depth research and information about the vaccines. Vaccines not given sufficient time to play itself out to prove what it could or could not do but impregnated into healthy human beans that eventually lead to the end of civilisation is still fictional. Ok, such a scenario is quite far fetch and likely not to happen. The manufacturers and scientists are willing to vouch for the safety of these vaccines, including Trump that still refused to be vaccinated. Manufacturers insisted that liabilities are waived for their used. It was reported that some employees of manufacturers of these vaccines refused to take them. Trump called it is the best Christmas present.
Word of caution, the normal test period for a vaccine before being approved for sale is 3 to 4 years. This is the time needed to make sure the vaccine is fairly safe. The western vaccines are now trumpeted to be safe after less than a year, approved by warp speed. So take care. Some side effects can take longer to appear.
My contention is, what if? The vaccines are very new and not fully tested. That is a fact. Singapore has taken a prudent approach. It is voluntary. There are other well tested options available.
PS. China did not rush the trials of its vaccines. And these were conducted by independent national bodies outside China, not by the Chinese manufacturers. Turkey is a Nato member and used to be hostile to China but conducted the trial and concluded that it is safe and 91% effective. Many Middle East countries are using the Chinese vaccines, including Indonesia and Latin America and African countries.